In vitro factor VIII recovery during the delivery of ultra-pure factor VIII concentrate by continuous infusion
نویسندگان
چکیده
منابع مشابه
FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY
Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...
متن کاملComparison of factor VIII-related von Willebrand factor proteins prepared from human cryoprecipitate and factor VIII concentrate.
Both commercial factor VIII concentrate and cryoprecipitate have factor VIII coagulant activity and factor VIII antigen (VIIIR:Ag). but the concentrate lacks the von Willebrand activity (VIIIR:WF) found in the cryoprecipitate. In an effort to find a possible cause for this anomaly we compared the structures of VlllR:WF proteins responsible for the VllIR:Ag and VlllR:WF activities obtained from ...
متن کاملModulation of human monocyte functions by factor VIII-anti-factor VIII complexes present in an affinity-purified factor VIII product.
A recent review article in Blood’ dealt with the advantage of using highly purified factor VI11 (F VIII) concentrates for the treatment of hemophilia. These products have a high specific activity of F VIIIC and, if properly treated, do not contain contaminating viruses. However, despite a relatively high purity, therapeutic concentrations of conventionally prepared F VI11 concentrates still hav...
متن کاملCombined Factor V and VIII Deficiency
This review summarizes current data on the pathomechanisms and new genetic findings of combined factor V and VIII deficiency (CF5F8D). Congenital haemorrhagic disorders characterized by deficiency of two clotting factors comprise an interesting group. Among dual coagulation disorders, CF5F8D is the most common type. For the first time combined factor V and VIII deficiency (F5F8D) was reported b...
متن کاملDetection of Factor VIII Inhibitors in Hemophilia A Patients
Background: Factor VIII administration to hemophilia A patients results in an immune response (inhibitor formation) which significantly complicates the therapy. The present study was performed to determine the prevalence of inhibitor development in hemophilia A patients receiving recombinant factor VIII therapy. Materials and Methods: This was an observational descriptive study. Clotting fac...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1996
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(199602)51:2<99::aid-ajh1>3.0.co;2-1